E2 Conjugating Enzymes 180 Products

There are predicted to be 38 E2 conjugating enzymes (of which Ubiquigent offer 32) and four classes (Class I-IV) of the enzyme exist, all of which contain a catalytic (Ubc) domain with an active site cysteine. After transfer of ubiquitin/UBL (ubiquitin-like modifier) from the E1 activating enzyme to the E2 via a transthiolation reaction, the loaded E2 interacts with E3 ligases to transfer the activated ubiquitin/UBL to the substrate lysine acceptor residue; either directly from the E2 or via a lysine residue on the E3 ligase itself.